The polyene macrolide antibiotics.

The polyene macrolide antibiotics.

The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.

N-glycosyl derivatives of polyene macrolide antibiotics.

Sir: The polyene macrolides are known as potent antifungal agents. However their use in therapy is limited by considerable toxicity and very poor water solubility. Many efforts had been taken to obvert these undesirable properties1-5). We report now a new group of derivatives of polyene macrolides exhibiting improved solubility in water and organic solvents and retaining the biological activity...

Chemistry and biology of the polyene macrolide antibiotics.

[This corrects the article on p. 166 in vol. 37, PMID: 4578757.].

The synthesis of amides of polyene macrolide antibiotics.

groups activated under the treatment with diphenyl phosphorazidate7) and triethylamine or N,N'-dicyclohexylcarbodiimide and I-hydroxy1 H-benzotriazole mixtures. The reaction was carried out in N,N-dimethylformamide or N,Ndimethylacetamide, at room temperature, using an excess of the reagents. The course of the reaction was followed by means of thin-layer chromatography on silica gel with the so...

Methyl esters of trimethylammonium derivatives of polyene macrolide antibiotics.